Overview
The application of single-cell chromatin accessibility data in heart research provides unprecedented insights into the mechanisms underlying cardiovascular diseases and their potential impacts on human health from an epigenetic perspective. The heart is a complex organ maintained by the coordinated efforts of various cell types to perform its normal physiological functions. Recognizing this complexity, we have developed CASHeart, a cardiac single-cell chromatin accessibility database.
As of now, CASHeart encompasses:- Data from 2 large-scale datasets encompassing 9 samples, including both adult and fetal donors.
- 105,704 cells in total, representing 30 distinct cell types, each accompanied by comprehensive cell type annotations.
- CASHeart provides low-dimensional embedding representations generated by various advanced models for scATAC data.
- Datasets for calling peaks both at the individual sample level and across the entire dataset are provided, facilitating more nuanced analyses.
