Enhancers are short (50-1500 bp) non-coding regions of DNA sequence that enhance the expression of target genes by recruiting regulatory proteins. Active enhancer regions carry particular chromatin marks, and their transcription produces noncoding eRNA. Notably, the eRNA set and corresponding enhancer set show enrichment for variants associated with distinct disorders (Yao et al., 2015).

      Although enhancers are among one of the least well-understood elements, emerging studies have revealed that enhancers play critical roles in a broad range of biological processes and are associated with numerous diseases, including cancer (Whyte et al., 2013), cardiovascular disease (Ounzain & Pedrazzini, 2018), and neurodegeneration disorder (Yao et al., 2015). Enhancers/eRNAs are becoming critically important for the understanding of life sciences, especially diseases.EnDisease is a manually curated database to collect enhancer-disease associations with the goal of promoting the development of computational methods for predicting enhancer-disease associations.

Currently, you can:

• browse the experimentally supported enhancer-disease association data;
• search the experimentally supported enhancer-disease association data;
• download the experimentally supported enhancer-disease association data;